Micronized composition containing Levonorgestrel

一种微粉化的含左炔诺孕酮的组合物

Abstract

The invention relates to a micronized composition containing Levonorgestrel, and aiming at the problem of low dissolution rate of the Levonorgestrel enteric coated preparation in the prior art, the invention provides the micronized composition containing Levonorgestrel. In the invention, 70 to 100 percent of Levonorgestrel is micronized to particles, and the grain diameter of each particle is less than or equal to 20 nanometers; the particles are combined with 60 to 97.9 percent of excipient to be prepared into a medicine core; and the medicine core is coated by a coating layer. The composition greatly improves the releasing degree and the peak time of the Levonorgestrel and Tmax.
本发明涉及一种微粉化的含左炔诺孕酮的药物组合物,现有技术中存在左炔诺孕酮肠溶制剂溶出速率低的问题,本发明提供一种微粉化的含左炔诺孕酮的组合物,通过将70-100%的左炔诺孕酮微粉化为粒径小于等于20微米的粒子,与重量比为60-97.9%的赋形剂制备成药芯,然后包裹包衣层。本发明的组合物大大提高了左炔诺孕酮的释放度和达峰时间。

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Cited By (5)

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    CN-102772377-ANovember 14, 2012北京以岭生物工程技术有限公司Preparation method for ultra-micro co-grinding levonorgestrel tablets
    CN-102772377-BSeptember 30, 2015北京以岭生物工程技术有限公司一种超微共粉碎左炔诺孕酮片的制备方法
    CN-103877058-AJune 25, 2014邵娜一种左炔诺孕酮片及其制备工艺
    CN-105796573-AJuly 27, 2016浙江仙琚制药股份有限公司Preparation method of levonorgestrel and ethinylestradiol tablets
    EP-2730284-A1May 14, 2014Naari AGLevonorgestrel-only-composition for optimized oral contraception with defined levonorgestrel content, dosage regimen and pharmaceutical preparation