Micronized composition containing Levonorgestrel



The invention relates to a micronized composition containing Levonorgestrel, and aiming at the problem of low dissolution rate of the Levonorgestrel enteric coated preparation in the prior art, the invention provides the micronized composition containing Levonorgestrel. In the invention, 70 to 100 percent of Levonorgestrel is micronized to particles, and the grain diameter of each particle is less than or equal to 20 nanometers; the particles are combined with 60 to 97.9 percent of excipient to be prepared into a medicine core; and the medicine core is coated by a coating layer. The composition greatly improves the releasing degree and the peak time of the Levonorgestrel and Tmax.




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Cited By (5)

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    CN-102772377-ANovember 14, 2012北京以岭生物工程技术有限公司Preparation method for ultra-micro co-grinding levonorgestrel tablets
    CN-102772377-BSeptember 30, 2015北京以岭生物工程技术有限公司一种超微共粉碎左炔诺孕酮片的制备方法
    CN-103877058-AJune 25, 2014邵娜一种左炔诺孕酮片及其制备工艺
    CN-105796573-AJuly 27, 2016浙江仙琚制药股份有限公司Preparation method of levonorgestrel and ethinylestradiol tablets
    EP-2730284-A1May 14, 2014Naari AGLevonorgestrel-only-composition for optimized oral contraception with defined levonorgestrel content, dosage regimen and pharmaceutical preparation