一种长效蛋白质药物及其制备方法

Long-acting protein medicament and preparation method thereof

Abstract

本发明公开了一种制备长效蛋白质药物及其制备方法,属于生物技术领域。具体地讲,本发明是通过对蛋白质药物进行改造,使之具有结合抗体Fc段的活性。改造后的蛋白质药物在血液中能够结合抗体的Fc段,从而与抗体形成大分子复合体,提高其体内的半衰期。由于半衰期的延长,改造后的蛋白质药物具有更持久的体内活性。
The invention discloses a long-acting protein medicament and a preparation method thereof, which belong to the field of biotechnology. Specifically, the method reconstructs a protein medicament so that the protein medicament has the activity for combining an Fc segment of an antibody. The reconstructed protein medicament can be combined with the Fc segment of the antibody in blood so as to form a macromolecular complex with the antibody and improve the in vivo half-life. Because the half-life is prolonged, the reconstructed protein medicament has more long-acting in vivo activity.

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