8-羟基-5-[(1r)-1-羟基-2[[(1r)-2-(4-甲氧基苯基)-1-甲基乙基]氨基]-乙基]-2(1h)-喹啉酮单盐酸盐的制备方法

Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]-ethyl]-2(1H)-quinolinone monohydrochloride

Abstract

本发明涉及式(I)的8-羟基-5-[(1R)-1-羟基-2[[(1R)-2-(4-甲氧基苯基)-1-甲基乙基]氨基]-乙基]-2(1H)-喹啉酮单盐酸盐的制备方法。还公开了用于所述方法的有用的中间体。
The invention relates to a process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2 [[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride of formula (I). Useful intermediates in the process are also disclosed.

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    CN-103889958-AJune 25, 2014阿尔米雷尔有限公司通过新的中间体制备5-(2-{[6-(2,2-二氟-2-苯基乙氧基)己基]氨基}-1(r)-羟基乙基)-8-羟基喹啉-2(1h)-酮的方法